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Oncogene cooperativity in Friend erythroleukemia: erythropoietin receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU.1, independent of SFFV proviral insertion

Cancer is a multi-step, multi-genetic event. Whether oncogenic mutations cooperate with one another to transform cells and how is not well understood. The Friend murine retroviral erythroleukemia model involves mitogenic activation of the erythropoietin receptor (EpoR) by the virus env gene (F-gp55)...

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Sonraí Bibleagrafaíochta
Main Authors: Afrikanova, Iva, Yeh, Ellen, Bartos, David, Watowich, Stephanie S, Longmore, Gregory D
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2002
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2388250/
https://ncbi.nlm.nih.gov/pubmed/11850847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj/onc/1205183
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