Evidence That Proline Focuses Movement of the Floppy Loop of Arylalkylamine N-Acetyltransferase (EC 2.3.1.87)

Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation of serotonin, the penultimate step in the synthesis of melatonin. Pineal AANAT activity increases at night in all vertebrates, resulting in increased melatonin production. This increases circulating levels of melatonin, thereby p...

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Autors principals: Pavlicek, Jiri, Coon, Steven L., Ganguly, Surajit, Weller, Joan L., Hassan, Sergio A., Sackett, Dan L., Klein, David C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Enzyme Catalysis and Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386931/
https://ncbi.nlm.nih.gov/pubmed/18362150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800593200
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