Evidence That Proline Focuses Movement of the Floppy Loop of Arylalkylamine N-Acetyltransferase (EC 2.3.1.87)

Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation of serotonin, the penultimate step in the synthesis of melatonin. Pineal AANAT activity increases at night in all vertebrates, resulting in increased melatonin production. This increases circulating levels of melatonin, thereby p...

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Detalhes bibliográficos
Main Authors: Pavlicek, Jiri, Coon, Steven L., Ganguly, Surajit, Weller, Joan L., Hassan, Sergio A., Sackett, Dan L., Klein, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386931/
https://ncbi.nlm.nih.gov/pubmed/18362150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800593200
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