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Identification of innate immunity genes and pathways using a comparative genomics approach
To reveal regulators of innate immunity, we used RNAi assays to monitor the immune response when genes are inhibited in Caenorhabditis elegans and mouse macrophages. Genes that altered innate immune responsiveness in C. elegans were validated in murine macrophages, resulting in the discovery of 11 g...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2383967/ https://ncbi.nlm.nih.gov/pubmed/18463287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802405105 |
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