Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.

The interferon-induced RNA-dependent protein kinase (PKR) is postulated to have an important regulatory role in the synthesis of viral and cellular proteins. Activation of the enzyme requires the presence of a suitable activator RNA and is accompanied by an autophosphorylation of PKR. Active PKR pho...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Thomis, D C, Samuel, C E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC238244/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7693978/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.12.7695-7700.1993
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