A large deletion in the matrix domain of the human immunodeficiency virus gag gene redirects virus particle assembly from the plasma membrane to the endoplasmic reticulum.

Morphogenesis of retroviruses involves assembly of the structural Gag and Gag-Pol polyproteins with subsequent budding of the virus particle from the plasma membrane and proteolytic cleavage by the viral proteinase. The matrix (MA) domain, representing the N-terminal segment of Gag, plays a critical...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Fäcke, M, Janetzko, A, Shoeman, R L, Kräusslich, H G
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237885/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8331736/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.8.4972-4980.1993
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