Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a key inhibitor of p53 and several mechanisms of MDM2/p53 interactions are presently known: modulating...

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Main Authors: Mittelstrass, Kirstin, Sauter, Wiebke, Rosenberger, Albert, Illig, Thomas, Timofeeva, Maria, Klopp, Norman, Dienemann, Hendrik, Meese, Eckart, Sybrecht, Gerhard, Woelke, Gabi, Cebulla, Mathias, Degen, Maria, Morr, Harald, Drings, Peter, Groeschel, Andreas, Kreymborg, Karsten Grosse, Haeußinger, Karl, Hoeffken, Gerd, Schmidt, Christine, Jilge, Bettina, Schmidt, Wilhelm, Ko, You-Dschun, Taeuscher, Dagmar, Chang-Claude, Jenny, Wichmann, Heinz-Erich, Bickeboeller, Heike, Risch, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377274/
https://ncbi.nlm.nih.gov/pubmed/18433484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-113
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