Association between telomere length and V(H) gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications

The immunoglobulin V(H) gene mutation status can divide B-cell chronic lymphocytic leukaemia (CLL) into two entities with a different clinical course. Cases with unmutated V(H) genes, considered to evolve from pregerminal centre (GC) cells, have a worse outcome compared to cases showing mutated V(H)...

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Detalhes bibliográficos
Main Authors: Hultdin, M, Rosenquist, R, Thunberg, U, Tobin, G, Norrback, K-F, Johnson, A, Sundström, C, Roos, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377180/
https://ncbi.nlm.nih.gov/pubmed/12592375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600763
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