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Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines
Transport system x(c)(−) is a member of plasma membrane heterodimeric amino-acid transporters and consists of two protein components, xCT and 4F2hc. This system mediates cystine entry coupled with the exodus of intracellular glutamate and regulates the intracellular glutathione (GSH) levels in most...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2377069/ https://ncbi.nlm.nih.gov/pubmed/12644836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600786 |
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