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Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines
Transport system x(c)(−) is a member of plasma membrane heterodimeric amino-acid transporters and consists of two protein components, xCT and 4F2hc. This system mediates cystine entry coupled with the exodus of intracellular glutamate and regulates the intracellular glutathione (GSH) levels in most...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2377069/ https://ncbi.nlm.nih.gov/pubmed/12644836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600786 |
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