Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines

Transport system x(c)(−) is a member of plasma membrane heterodimeric amino-acid transporters and consists of two protein components, xCT and 4F2hc. This system mediates cystine entry coupled with the exodus of intracellular glutamate and regulates the intracellular glutathione (GSH) levels in most...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Okuno, S, Sato, H, Kuriyama-Matsumura, K, Tamba, M, Wang, H, Sohda, S, Hamada, H, Yoshikawa, H, Kondo, T, Bannai, S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2003
Pynciau:
Experimental Therapeutics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377069/
https://ncbi.nlm.nih.gov/pubmed/12644836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600786
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