Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines

Transport system x(c)(−) is a member of plasma membrane heterodimeric amino-acid transporters and consists of two protein components, xCT and 4F2hc. This system mediates cystine entry coupled with the exodus of intracellular glutamate and regulates the intracellular glutathione (GSH) levels in most...

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Библиографические подробности
Главные авторы: Okuno, S, Sato, H, Kuriyama-Matsumura, K, Tamba, M, Wang, H, Sohda, S, Hamada, H, Yoshikawa, H, Kondo, T, Bannai, S
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2003
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377069/
https://ncbi.nlm.nih.gov/pubmed/12644836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600786
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