Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines

Transport system x(c)(−) is a member of plasma membrane heterodimeric amino-acid transporters and consists of two protein components, xCT and 4F2hc. This system mediates cystine entry coupled with the exodus of intracellular glutamate and regulates the intracellular glutathione (GSH) levels in most...

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Autors principals: Okuno, S, Sato, H, Kuriyama-Matsumura, K, Tamba, M, Wang, H, Sohda, S, Hamada, H, Yoshikawa, H, Kondo, T, Bannai, S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2003
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377069/
https://ncbi.nlm.nih.gov/pubmed/12644836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600786
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