Restored T-cell activation mechanisms in human tumour-infiltrating lymphocytes from melanomas and colorectal carcinomas after exposure to interleukin-2

We investigated the effects of interleukin-2 (IL-2) exposure on T-cell signal transduction molecules and apoptosis markers in tumour-infiltrating lymphocytes (TIL) isolated from 20 melanoma and 16 colorectal carcinoma metastases and expanded in vitro for therapeutic reinfusion. Before IL-2 culture,...

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Detalhes bibliográficos
Main Authors: De Paola, F, Ridolfi, R, Riccobon, A, Flamini, E, Barzanti, F, Granato, A M, Mordenti, G L, Medri, L, Vitali, P, Amadori, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377057/
https://ncbi.nlm.nih.gov/pubmed/12610520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600679
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