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Unusual regioselectivity and active site topology of human cytochrome P450 2J2
The oxidation of six derivatives of terfenadone by recombinant human CYP2J2 was studied by HPLC coupled to mass spectrometry (MS) using tandem MS techniques and by (1)H NMR spectroscopy. CYP2J2 exhibited a surprising regioselectivity in favor of the hydroxylation of the substrate terminal chain at t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2377029/ https://ncbi.nlm.nih.gov/pubmed/17705402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700876a |
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