The adenovirus L3 23-kilodalton proteinase cleaves the amino-terminal head domain from cytokeratin 18 and disrupts the cytokeratin network of HeLa cells.

Immunofluorescence studies revealed that adenovirus induces a reorganization of the cytokeratin system in lytically infected HeLa cells. At 24 h postinfection, the cytokeratin network began to disassemble into prominent spheroid globules. By 36 h postinfection, host cell lysis occurred, accompanied...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Chen, P H, Ornelles, D A, Shenk, T
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237697/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7684469/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.6.3507-3514.1993
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