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An anti-MUC1-antibody–interleukin-2 fusion protein that activates resting NK cells to lysis of MUC1-positive tumour cells

MUC1 mucin is aberrantly glycosylated and overexpressed in a number of epithelial malignancies and is therefore a promising tumour-associated antigen for target-directed immunotherapy of a panel of malignant diseases. In MUC1-positive tumours, MHC class I expession is frequently downregulated and MU...

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Detalhes bibliográficos
Main Authors: Heuser, C, Ganser, M, Hombach, A, Brand, H, Denton, G, Hanisch, F-G, Abken, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376954/
https://ncbi.nlm.nih.gov/pubmed/12966437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601267
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