Protracted infusional 5-fluorouracil plus high-dose folinic acid combined with bolus mitomycin C in patients with gastrointestinal cancer: a phase I/II dose escalation study

The aim of this study was to define the maximum tolerated dose (MTD) of bolus mitomycin C (MMC) in combination with 24 h-continuous infusion of 5-flourouracil (FU) plus folinic acid, and to assess the toxicity and activity in patients with previously treated colorectal and gastric cancer. Escalating...

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Autori principali: Hartmann, J T, Oechsle, K, Quietzsch, D, Wein, A, Hofheinz, R D, Honecker, F, Nehls, O, Köhne, C-H, Käfer, G, Kanz, L, Bokemeyer, C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2003
Soggetti:
Clinical
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376864/
https://ncbi.nlm.nih.gov/pubmed/14647137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601412
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