Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding.

Human papillomavirus type 18 (HPV-18) E7 proteins bind zinc through Cys-X-X-Cys repeats located at the C terminus of the protein. In order to examine the role of these cysteine motifs in E7 function, we expressed the HPV-18 E7 protein in bacteria and found that purified E7 forms a dimer through inte...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: McIntyre, M C, Frattini, M G, Grossman, S R, Laimins, L A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237652/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8497045/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.6.3142-3150.1993
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