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Do altering in ornithine decarboxylase activity and gene expression contribute to antiproliferative properties of COX inhibitors?

Two isoforms of cyclooxygenase (COX) participate in growth control; COX-1 is constitutively expressed in most cells, and COX-2 is an inducible enzyme in response to cellular stimuli. An induction of COX-2 found in neoplastic tissues results in increased cell growth, inhibition of apoptosis, activati...

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Autori principali: Ostrowski, J, Wocial, T, Skurzak, H, Bartnik, W
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376368/
https://ncbi.nlm.nih.gov/pubmed/12671717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600815
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