Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites.

Processing of the hepatitis C virus (HCV) H strain polyprotein yields at least nine distinct cleavage products: NH2-C-E1-E2-NS2-NS3-NS4A-NS4B-NS5A-NS5B-CO OH. As described in this report, site-directed mutagenesis and transient expression analyses were used to study the role of a putative serine pro...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Grakoui, A, McCourt, D W, Wychowski, C, Feinstone, S M, Rice, C M
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1993
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237608/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386278/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.5.2832-2843.1993
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