p19(Arf) induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation

The Ink4a/Arf locus encodes p16(Ink4a) and p19(Arf) and is among the most frequently mutated tumor suppressor loci in human cancer. In mice, many of these effects appear to be mediated by interactions between p19(Arf) and the p53 tumor-suppressor protein. Because Tp53 mutations are a common feature...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Radfar, Arash, Unnikrishnan, Indira, Lee, Han-Woong, DePinho, Ronald A., Rosenberg, Naomi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1998
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23757/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9789064/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.22.13194
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