Neutralization of a negative charge in the S1–S2 region of the K(V)7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy

The voltage-gated potassium channels K(V)7.2 and K(V)7.3 (genes KCNQ2 and KCNQ3) constitute a major component of the M-current controlling the firing rate in many neurons. Mutations within these two channel subunits cause benign familial neonatal convulsions (BFNC). Here we identified a novel BFNC-c...

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Autors principals: Wuttke, Thomas V, Penzien, Johann, Fauler, Michael, Seebohm, Guiscard, Lehmann-Horn, Frank, Lerche, Holger, Jurkat-Rott, Karin
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2008
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375582/
https://ncbi.nlm.nih.gov/pubmed/18006581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.143826
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