Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1

PTEN is a candidate tumour suppressor gene and frequently mutated in multiple cancers, however, not in pancreatic cancer. Recently, it has been demonstrated that PTEN expression is regulated by TGF-β1. Using TGF-β1 transgenic mice (n=7) and wildtype littermates (n=6), as well as pancreatic tissues o...

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Bibliografiske detaljer
Main Authors:	Ebert, M P A, Fei, G, Schandl, L, Mawrin, C, Dietzmann, K, Herrera, P, Friess, H, Gress, T M, Malfertheiner, P
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2002
Fag:	Molecular and Cellular Pathology
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2375189/ https://ncbi.nlm.nih.gov/pubmed/11870516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600031
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Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1

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