Loss of expression of HDAC-recruiting methyl-CpG-binding domain proteins in human cancer

Dysregulation of CpG-methylation is a common feature of many human cancers and tumour suppressor genes can be silenced by hypermethylation. Recently, 2 methyl-CpG-binding domain proteins have been linked to gene inactivation by their ability to recruit co-repressors and HDAC-activity to methylated g...

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Bibliographic Details
Main Authors: Müller-Tidow, C, Kügler, K, Diederichs, S, Klümpen, S, Möller, M, Vogt, U, Metzger, R, Schneider, P M, Berdel, W E, Serve, H
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2001
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Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375156/
https://ncbi.nlm.nih.gov/pubmed/11710831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.2041
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