Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two Unrelated Antiprion Drugs

BACKGROUND: 6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based assay. These structurally unrelated molecules are also active against mammalian prion in several cell-based assays and in vivo in...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Tribouillard-Tanvier, Déborah, Dos Reis, Suzana, Gug, Fabienne, Voisset, Cécile, Béringue, Vincent, Sabate, Raimon, Kikovska, Ema, Talarek, Nicolas, Bach, Stéphane, Huang, Chenhui, Desban, Nathalie, Saupe, Sven J., Supattapone, Surachai, Thuret, Jean-Yves, Chédin, Stéphane, Vilette, Didier, Galons, Hervé, Sanyal, Suparna, Blondel, Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374897/
https://ncbi.nlm.nih.gov/pubmed/18478094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002174
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky