Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two Unrelated Antiprion Drugs

BACKGROUND: 6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based assay. These structurally unrelated molecules are also active against mammalian prion in several cell-based assays and in vivo in...

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Detalhes bibliográficos
Main Authors: Tribouillard-Tanvier, Déborah, Dos Reis, Suzana, Gug, Fabienne, Voisset, Cécile, Béringue, Vincent, Sabate, Raimon, Kikovska, Ema, Talarek, Nicolas, Bach, Stéphane, Huang, Chenhui, Desban, Nathalie, Saupe, Sven J., Supattapone, Surachai, Thuret, Jean-Yves, Chédin, Stéphane, Vilette, Didier, Galons, Hervé, Sanyal, Suparna, Blondel, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374897/
https://ncbi.nlm.nih.gov/pubmed/18478094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002174
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