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Activation of TRPP2 through mDia1-dependent voltage gating
The TRPP2 cation channel is directly responsible for ∼15% of all cases of autosomal dominant polycystic kidney disease. However, the mechanisms underlying fundamental properties of TRPP2 regulation, such as channel gating and activation, are unknown. We have shown that TRPP2 was activated by EGF and...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374846/ https://ncbi.nlm.nih.gov/pubmed/18388856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.70 |
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