Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport

The human multidrug transporter MDR1 P-glycoprotein and the multidrug resistance proteins MRP1 and MRP2 transport a range of cytotoxic drugs, resulting in multidrug resistance in tumour cells. To overcome this form of drug resistance in patients, several inhibitors (reversal agents) of these transpo...

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Bibliographic Details
Main Authors: Evers, R, Kool, M, Smith, A J, Deemter, L van, Haas, M de, Borst, P
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2000
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374556/
https://ncbi.nlm.nih.gov/pubmed/10917553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1260
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