Anti-tumour effects and pharmacokinetic profile of 17-(5′ -isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: an inhibitor of androgen synthesis

17-(5′-Isoxazolyl)androsta-4,16-dien-3-one (L-39), a novel androstene derivative, was synthesized and evaluated in vitro and in vivo. L-39 showed potent and non-competitive inhibition of human testicular microsomal 17α-hydroxylase/C (17,20)-lyase with an IC (50) value of 59 n M and K(i) of 22 n M. L...

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Autors principals: Nnane, I P, Long, B J, Ling, Y-Z, Grigoryev, D N, Brodie, A M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2000
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374539/
https://ncbi.nlm.nih.gov/pubmed/10883671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1136
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