Osteoblastic differentiation and P-glycoprotein multidrug resistance in a murine osteosarcoma model

A recent study of multidrug resistance (MDR) 1 gene transfected osteosarcoma cells found a cause-effect relationship between increased expression of P-glycoprotein (P-gp) and a low aggressive phenotype. However, several experimental and clinical studies have observed contradictory findings in that P...

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Autori principali: Takeshita, H, Kusuzaki, K, Murata, H, Suginoshita, T, Hirata, M, Hashiguchi, S, Ashihara, T, Gebhardt, M C, Mankin, H J, Hirasawa, Y
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2000
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Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374486/
https://ncbi.nlm.nih.gov/pubmed/10755409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.1099
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