A prolonged methoxymorpholino doxorubicin (PNU-152243 or MMRDX) infusion schedule in patients with solid tumours: a phase 1 and pharmacokinetic study

The aim of this phase I study was to assess feasibility, pharmacokinetics and toxicity of methoxymorpholino doxorubicin (MMRDX or PNU-152243) administered as a 3 h intravenous infusion once every 4 weeks. Fourteen patients with intrinsically anthracycline-resistant tumours received 37 cycles of MMRD...

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Main Authors: Fokkema, E, Verweij, J, van Oosterom, A T, Uges, D R A, Spinelli, R, Valota, O, de Vries, E G E, Groen, H J M
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2000
主題:
Regular Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374418/
https://ncbi.nlm.nih.gov/pubmed/10732743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.0996
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