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Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs

Previous work has shown platinum drugs to differ in their effects on the peripheral nervous system. To test whether their differential toxicity was due to differences in their partitioning into the peripheral nervous system, we correlated the hydrophobicity, reactivity, tissue accumulation and neuro...

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Detalhes bibliográficos
Main Authors: Screnci, D, McKeage, M J, Galettis, P, Hambley, T W, Palmer, B D, Baguley, B C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374394/
https://ncbi.nlm.nih.gov/pubmed/10732773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.1026
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