Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumourcells

The aim of the present study was to assess the cytotoxicity of manumycin, a specific inhibitor of farnesyl:protein transferase, as well as its effects on protein isoprenylation and kinase-dependent signal transduction in COLO320-DM human colon adenocarcinoma which harbours a wild-type K- ras gene. I...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Paolo, A Di, Danesi, R, Nardini, D, Bocci, G, Innocenti, F, Fogli, S, Barachini, S, Marchetti, A, Bevilacqua, G, Tacca, M Del
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2000
Aiheet:
Regular Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374379/
https://ncbi.nlm.nih.gov/pubmed/10732765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.1018
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