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Population pharmacokinetics in phase I drug development: a phase I study of PK1 in patients with solid tumours

Doxorubicin pharmacokinetics were determined in 33 patients with solid tumours who received intravenous doses of 20–320 mg m(−2) HPMA copolymer bound doxorubicin (PK1) in a phase I study. Since assay constraints limited the data at lower doses, conventional analysis was not feasible and a ‘populatio...

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Hlavní autoři: Thomson, A H, Vasey, P A, Murray, L S, Cassidy, J, Fraier, D, Frigerio, E, Twelves, C
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374352/
https://ncbi.nlm.nih.gov/pubmed/10487619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690657
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