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Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer
We have studied a set of 40 human lobular breast cancers for loss of heterozygosity (LOH) at various chromosome locations and for mutations in the coding region plus flanking intron sequences of the E-cadherin gene. We found a high frequency of LOH (100%, 31/31) at 16q21–q22.1. A significantly highe...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
1999
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374316/ https://ncbi.nlm.nih.gov/pubmed/10584868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690815 |
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