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Cavities of α(1)-antitrypsin that play structural and functional roles
The native form of inhibitory serine protease inhibitors (serpins) is strained, which is critical for their inhibitory activity. Previous studies on stabilizing mutations of α(1)-antitrypsin, a prototype of serpins, indicated that cavities provide a structural basis for the native strain of the mole...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374102/ https://ncbi.nlm.nih.gov/pubmed/11420446 |
| Oznake: |
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