Increased Aortic Calpain-1 Activity Mediates Age-Associated Angiotensin II Signaling of Vascular Smooth Muscle Cells

BACKGROUND: Angiotensin II (Ang II) signaling, including matrix metalloproteinase type II (MMP2) activation, has been linked to an age-associated increase in migration capacity of vascular smooth muscle cells (VSMC), and to other proinflammatory features of arterial aging. Calpain-1 activation is re...

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Bibliographic Details
Main Authors: Jiang, Liqun, Wang, Mingyi, Zhang, Jing, Monticone, Robert E., Telljohann, Richard, Spinetti, Gaia, Pintus, Gianfranco, Lakatta, Edward G.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373882/
https://ncbi.nlm.nih.gov/pubmed/18493299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002231
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