Neutralizing monoclonal antibodies that distinguish three antigenic sites on human cytomegalovirus glycoprotein H have conformationally distinct binding sites.

Seven neutralizing murine monoclonal antibodies specific for the glycoprotein H of human cytomegalovirus were produced and used to construct a topological map of two nonoverlapping antigenic sites that are bridged by a third antigenic site. Neutralization assays with 15 laboratory or clinical human...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Simpson, J A, Chow, J C, Baker, J, Avdalovic, N, Yuan, S, Au, D, Co, M S, Vasquez, M, Britt, W J, Coelingh, K L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237386/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7677958/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.1.489-496.1993
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