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Thoroughly sampling sequence space: Large-scale protein design of structural ensembles

Modeling the inherent flexibility of the protein backbone as part of computational protein design is necessary to capture the behavior of real proteins and is a prerequisite for the accurate exploration of protein sequence space. We present the results of a broad exploration of sequence space, with...

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Detalhes bibliográficos
Main Authors: Larson, Stefan M., England, Jeremy L., Desjarlais, John R., Pande, Vijay S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373757/
https://ncbi.nlm.nih.gov/pubmed/12441379
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