Structural characterization of the N-terminal autoregulatory sequence of phenylalanine hydroxylase

Phenylalanine hydroxylase (PAH) is activated by its substrate phenylalanine, and through phosphorylation by cAMP-dependent protein kinase at Ser16 in the N-terminal autoregulatory sequence of the enzyme. The crystal structures of phosphorylated and unphosphorylated forms of the enzyme showed that, i...

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Bibliographic Details
Main Authors: Horne, James, Jennings, Ian G., Teh, Trazel, Gooley, Paul R., Kobe, Bostjan
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373677/
https://ncbi.nlm.nih.gov/pubmed/12142458
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