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Substrate entropy in enzyme enantioselectivity: An experimental and molecular modeling study of a lipase

The temperature dependence of the enantioselectivity of Candida antarctica lipase B for 3-hexanol, 2-butanol, 3-methyl-2-butanol, 3,3-dimethyl-2-butanol, and 1-bromo-2-butanol revealed that the differential activation entropy, Δ(R−S)ΔS(‡), was as significant as the differential activation enthalpy,...

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Detalhes bibliográficos
Main Authors: Ottosson, Jenny, Fransson, Linda, Hult, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373621/
https://ncbi.nlm.nih.gov/pubmed/12021445
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