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An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor
Down-regulation of activated and ubiquitinated growth factor (GF) receptors by endocytosis and subsequent lysosomal degradation ensures attenuation of GF signaling. The ubiquitin-binding adaptor protein Eps15 (epidermal growth factor receptor [EGFR] pathway substrate 15) functions in endocytosis of...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373575/ https://ncbi.nlm.nih.gov/pubmed/18362181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200708115 |
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