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Mutations in the cytoplasmic domain of human immunodeficiency virus type 1 transmembrane protein impair the incorporation of Env proteins into mature virions.

In-frame stop codons were introduced into the coding region of human immunodeficiency virus type 1 (HIV-1) transmembrane protein (gp41). Truncation of 147 amino acids from the carboxyl terminus of gp41 (TM709) significantly decreased the stability and cell surface expression of the viral Env protein...

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Библиографические подробности
Опубликовано в::J Virol
Главные авторы: Yu, X, Yuan, X, McLane, M F, Lee, T H, Essex, M
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 1993
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237354/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8416370/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.1.213-221.1993
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