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Histidine pK(a) shifts and changes of tautomeric states induced by the binding of gallium-protoporphyrin IX in the hemophore HasA(SM)

The HasA(SM) hemophore, secreted by Serratia marcescens, binds free or hemoprotein bound heme with high affinity and delivers it to a specific outer membrane receptor, HasR. In HasA(SM), heme is held by two loops and coordinated to iron by two residues, His 32 and Tyr 75. A third residue His 83 was...

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Detalhes bibliográficos
Main Authors: Wolff, Nicolas, Deniau, Clarisse, Létoffé, Sylvie, Simenel, Catherine, Kumar, Veena, Stojiljkovic, Igor, Wandersman, Cécile, Delepierre, Muriel, Lecroisey, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373534/
https://ncbi.nlm.nih.gov/pubmed/11910020
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