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Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIα

Staphylococcal enterotoxins (SEs) are superantigenic protein toxins responsible for a number of life-threatening diseases. The X-ray structure of a staphylococcal enterotoxin A (SEA) triple-mutant (L48R, D70R, and Y92A) vaccine reveals a cascade of structural rearrangements located in three loop reg...

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Détails bibliographiques
Auteurs principaux: Krupka, Heike I., Segelke, Brent W., Ulrich, Robert G., Ringhofer, Sabine, Knapp, Mark, Rupp, Bernhard
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2002
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373479/
https://ncbi.nlm.nih.gov/pubmed/11847286
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