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Propagation of a single destabilizing mutation throughout the Escherichia coli ribonuclease HI native state
A point mutation (I53A) in the core of Escherichia coli RNase H* is known to destabilize both the native conformation (ΔG(UN)) and the kinetic intermediate (ΔG(UI)) by 2 kcal/mole. Here, we have used native-state hydrogen deuterium exchange to ask how this destabilization is propagated throughout th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373462/ https://ncbi.nlm.nih.gov/pubmed/11847275 |
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