Multiple diverse ligands binding at a single protein site: A matter of pre-existing populations

Here, we comment on the steadily increasing body of data showing that proteins with specificity actually bind ligands of diverse shapes, sizes, and composition. Such a phenomenon is not surprising when one considers that binding is a dynamic process with populations in equilibrium and that the shape...

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Bibliographic Details
Main Authors: Ma, Buyong, Shatsky, Maxim, Wolfson, Haim J., Nussinov, Ruth
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2002
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373439/
https://ncbi.nlm.nih.gov/pubmed/11790828
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