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Orientation-specific cis complementation by bulge- and loop-mutated human immunodeficiency virus type 1 TAR RNAs.

Tat activates human immunodeficiency type 1 gene expression by binding to TAR RNA. TAR comprises a partially base paired stem and hexanucleotide loop with a tripyrimidine bulge in the upper stem. In vitro, Tat binds to the bulge and upper stem, with no requirement for the loop. However, in vivo, loo...

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Published in:J Virol
Main Authors: Braddock, M, Powell, R, Sutton, J, Kingsman, A J, Kingsman, S M
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237310/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7966633/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.12.8396-8400.1994
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