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Thermal inactivation of oral polio vaccine: contribution of RNA and protein inactivation.
Heating the Sabin strains of poliovirus at 42 to 45 degrees C caused inactivation, loss of native antigen, and release of the viral RNA (vRNA). The loss of virion infectivity exceeded the loss of vRNA infectivity (as measured by transfection) by roughly 2 log10. Pirodavir inhibited the loss of nativ...
Gardado en:
| Publicado en: | J Virol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology (ASM)
1994
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237065/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8083982/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.10.6454-6457.1994 |
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