Protection against lethal lymphocytic choriomeningitis virus (LCMV) infection by immunization of mice with an influenza virus containing an LCMV epitope recognized by cytotoxic T lymphocytes.

The reverse genetics system has made it possible to modify the influenza virus genome. By this method, we were able to assess influenza virus as a vaccine vector for protecting BALB/c mice against otherwise lethal lymphocytic choriomeningitis virus (LCMV) infection. A single dose of influenza virus...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Castrucci, M R, Hou, S, Doherty, P C, Kawaoka, Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236851/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7514676/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.6.3486-3490.1994
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