Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2.

The fusion (F) protein of human parainfluenza virus type 3 contains the tribasic cleavage site R-T-K-R, which was altered by site-directed mutagenesis. Wild-type F protein and various mutants were expressed by recombinant vaccinia viruses. The endogenous endoprotease present in CV-1 cells cleaves F...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ortmann, D, Ohuchi, M, Angliker, H, Shaw, E, Garten, W, Klenk, H D
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236759/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8139055/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.4.2772-2776.1994
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